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JAN-MAR 2016
Circadian and other rhythmic changes in biological susceptibility and response of organisms to a large variety of physical and chemical agents including medications and food are rather common phenomena. Time related differences in drug effects depend upon endogenous circadian rhythms, which include metabolic pathways. The study of rhythmic, predictable in time differences in time effects or pharmacokinetics of drugs both in experimental animals and in men is called chronopharmacology. It investigates the side effects of drugs upon temporal changes in biological functions or symptoms of a disease as well as drug effects as a function of biological timing. In this review, we will focus on mammalian chronopharmacology of hypertensive drugs. Moreover, we will try to discuss about the physiological effects of drugs on the body, the mechanism of drug action, the relationship between drug concentration and effect in relation to circadian clock.
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