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IJAPGR OCT-DEC 2015
A Role of Supramolecular Systems in Targeting Drug Delivery to Specific Sites-A Review
Krishnamoorthy.B*, Muthukumran.M and Sumithira G

This review aims to presenting importance of supramolecular chemistry in the development of new pharmaceutical therapies by understanding the interactions at a drug binding site. The area of drug delivery has also made critical advances as a result of supramolecular system providing encapsulation and targeted release mechanisms. In addition, various supramolecular systems can be used as drug carriers to alter physicochemical and pharmacokinetic characteristics of drugs. Representative supramolecular systems that can be used for this purpose include surfactant/polymer micelles, microemulsions, liposomes, layer-by-layer assemblies and various molecular conjugates. Especially, microemulsions have been used oral drug delivery of poorly soluble drugs to improvements in bioavailability and predictable of absorption behavior. Neoral®, an immunosuppressant used after transplant operations, is one of the most famous microemulsion-based drugs; liposomes are established supramolecular drug carriers, which have already been marketed in formulations including “AmBisome”, “Visudyne”, and “Doxil”.  This review signifies supramolecular drug delivery systems which may improve usability of drug candidates or add worth to existing drugs are introduced.
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