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IJAPGR OCT-DEC 2013
Antiurolithiatic activity of Nardostachys jatamansi DC on Modified Lithogenic Diet induced urolithiasis in rats
Vidhya.G*, Sumithira.G, Anandhan.R, Anand.G
In an indigenous system of medicine, the rhizomes of Nardostachys jatamansi DC (family- Valerianaceae) to be useful in the treatment of urinary stone. Hence, in this present study the rhizome of N. jatamansi DC has been selected for its antiurolithiatic activity on experimentally induced urolithiatic rats. Antiurolithiatic activity of N. jatamansi DC was carried out on a modified lithogenic diet (30% lactose rich diet and 1% ethylene glycol) induced urolithiasis in rats. Treatment with hydroalcoholic extract (400mg/kg, p.o) of N. jatamansi DC significantly lowered (P<0.001) the increased levels of calcium, oxalate, phosphate, magnesium, urea & uric acid in serum & urine and significantly reduced (P<0.001) their retention in the kidneys. The histopathological study of the kidney also supported the above results. The results were comparable to that of the standard drugs (Cystone). The presented data indicate that administration of N. jatamansi DC rhizome extract in rats with experimentally-induced urolithiasis is reduced and also prevented the formation of urinary stones, supporting folk information regarding the antiurolithiatic activity of the plant. The reduction in the stone forming constituents in urine and renal tissue brought about N. jatamansi DC by could contribute to its antiurolithiatic property.
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