ISSN 2347 - 5102
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IJAPGR SEPT 2013
Antidiabetic and Hypolipidemic activities of momordica tuberosa unripe fruit extract on diabetic induced rats
Palanivel. V *, Mohammed Shafi, Senthil Kumar K.L
The aim of this research was to investigate antidiabetic and antilipidemic activities of momordica tuberosa unripe fruit extract on streptozotocin induced diabetic albino rats. Alcoholic extract of momordica tuberosa was prepared with dried unripe fruit powder & 80% ethanol and subjected to phytochemical screening tests. Preliminary phytochemical investigations showed the presence of glycosides, flavonoids, saponins in ethanolic extract which are proved to act as potent antioxidants indicating the possibility of the antidiabetic nature. Selection of dose was made on the basis of acute oral toxicity study as per OECD guidelines 423. A comparison was made between the action of momordica tuberosa extract and glibenclamide (6mg/kg body wt.). Albino rats were divided into groups for normal control, diabetic control, diabetic treated with GBC (6mg/kg BW) and diabetic received momordica tuberosa (150 & 300 mg/kg BW). Ethanolic extract of momordica tuberosa unripe fruit possess significant (P<0.05) hypoglycemic potential in STZ induced hyperglycemic rats and showed significant improvement in the lipid profile comparable to glibenclamide treated group. However, improvement in lipid profile was less than that achieved with the standard drug glibenclamide.
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