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IJAPGR OCT-DEC 2013
Evaluation of hypoglycemic activity of Costus igneus extract (whole plant) on alloxan induced diabetic rats
V.Palanivel * , Mohamed Jihad E .V, K.L. Senthil Kumar
Our present study was to evaluate hypoglycemic activity of Costus igneus (whole plant) ethanolic extract on alloxan induced diabetic albino wister strain rats. The ethanolic extract from whole plant of Costus igneus (ECI) was prepared and subjected to preliminary photochemical analyses to know the presence of alkaloids, flavanoid, phenolic compounds and steroids.Normal as well as diabetic rats was divided into groups (n=6) receiving different treatments i.e vehicle( diabetic control), standard drug, ethanolic extract of Costus igneus. Blood samples was collected and analyzed for fasting blood glucose levels (BGL) and lipid profile on days 0,7, and 14. Diabetic rats treated with Glibenclamide (10mg/kg) decreased blood glucose level from 245.66 ± 2.40 mg/dl to 95.00 ± 1.34 mg/dl (55.33%). Diabetic rats treated with ethanolic extract of Costus igneous (ECI) 250mg/kg showed decreased blood glucose levels from 243.83 ± 3.4mg/kg to 90.17 ± 5.04 mg/kg (50.46 %) at the end of 14th day of treatment indicating good hypoglycemic activity. Costus igneous ethanolic extract treated animals also showed decrease in serum cholesterol & serum triglyceride, LDL along with increase in HDL as compared to diabetic control group.
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