ISSN 2347 - 5102
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IJAPGR SEPT 2013
Evaluation of Antidiabetic activity of Barringtonia acutangula (L.Gaertn) leaf extract in Alloxan induced Diabetic rats
Palanivel. V * Sabeel Kuttiyil, Senthil Kumar K.L.
The present study was investigated the Antidiabetic effect of oral administration of ethanolic leaf extract of Barringtonia acutangula (L.Gaertn) in normal and Alloxan induced diabetic rats. Albino Wistar strain rats (150 to 200 gm) were induced diabetic condition by administration of Alloxan (150mg/kg bw) intraperitoneally. Extract of Barringtonia acutangula (L.Gaertn) leaves was orally administrated to normal and Alloxan induced diabetic rats for 21 days to determine the antidiabetic activity. Serum and tissue biochemical analysis including fasting blood sugar level in normal and Alloxan induced diabetic rats were investigated. Administration of Alloxan 150mg/kg (i.p) lead to elevation of fasting blood glucose levels, along with significant decrease in body weight over a period of 21 days and it was partially restored or improved upon administration of Barringtonia acutangula. Ethanolic extract (250 and 500 mg/kg bw/day) shows significantly (P<0.01) decreased 40-50% of the elevated blood glucose level , cholesterol, triglycerides , urea, creatinine , billirubin comparison to untreated diabetic Wister strain albino rats 21 days of daily treatment
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