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IJAPGR SEPT 2013
Evaluation of Tramadol Hydrochloride Loaded Calcium Alginate Beads
B. Krishnamoorthy*, Sanchita Mandal, S. Senthil Kumar & S.K. Basu
In this study, an attempt was made to develop oral sustained delivery formulations based on ionotropic gelation of sodium alginate using calcium chloride as the cross-linking agent. Tramadol hydrochloride was either incorporated into preformed calcium alginate gel beads (Method-1) or simultaneously incorporated during the gelation of sodium alginate by calcium chloride (Method-II). The beads prepared by the method I resulted in higher drug loading when compared to those prepared by the method II. The morphology of the beads was studied by means of scanning electron microscopy (SEM) and the physical state of the drug in formulations was characterized using X-ray powder diffraction analysis (X-RD) and differential scanning calorimetry (DSC). The results indicated that the drug was present in an amorphous state in the case of beads prepared by method I. The drug - polymer interactions were evaluated using FTIR and no interaction between the drug and polymer was observed. The in-vitro drug release was studied using USP XXIII (type II) dissolution test apparatus with distilled water as the medium. Further, the release data was analyzed to understand the mechanism of drug release and it was found to follow diffusion model. From this present study, it can be concluded that tramadol hydrochloride loaded calcium alginate beads prepared by ionotropic gelation method with calcium chloride as the cross-linking agent can be utilized for the development of a sustained release drug delivery system for tramadol hydrochloride.
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