ISSN 2347 - 5102
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IJAPGR SEPT 2013
In vitro and in vivo anticancer activity of hydro-alcoholic extract of Ipomoea carnea leaf against Ehrlich Ascites Carcinoma cell lines
G. Anand*, G. Sumithira, R. Chinna Raja, A. Muthukumar, G. Vidhya
The plant Ipomoea carnea Jacq (Family: convolvulacaea) have been traditionally used for many ailments including cancer, though information from organized search of published literature does not provide sufficient evidence for its antitumor activities, so we made an attempt to use Hydroalcoholic Extract of Ipomoea carnea (HAEIC) for studying anticancer activity by using both in-vitro and in-vivo method. The In-vitro anticancer activity of HAEIC was evaluated by the MTT assay method using Ehrlich Ascites Carcinoma (EAC) cell lines. Later the extract subjected to in-vivo anticancer therapy using EAC tumor model. The activity was assessed increase in life span, average increase in body weight, change in food intake, tumor weight, tumor volume, viable cell count, non viable cell count, packed cell volume, hematological and biochemical parameters. The potency of the extract was compared with standard 5-flurouracil (20mg/kg i.p). In-vitro anticancer activity of HAEIC exhibit significant cytotoxicity against EAC cell lines at different concentration. Oral administration of HAEIC at the dose of 250 and 500mg/kg, significantly (p<0.001) increased the survival time, non viable cell count and decrease in body weight, food intake and viable cell count of the tumor bearing mice. After 14 days of inoculation, HAEIC was able to reverse the changes in the hematological parameters, protein and packed cell volume. The results indicate that HAEIC possess significant antitumor activity on dose dependent manner
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