ISSN 2347 - 5102
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IJAPGR SEPT 2013
Wound-healing potential of aqueous and ethanolic extracts of thespesia macrophylla blume. roots - A preliminary study
Swetha. P*, RajKumar. M, Krishnamoorthy.B, Muthukumaran.M,Sujana.V
Thespesia macrophylla blume is a medicinal plant which is used from time immemorial for treatment of various disorders especially cuts, burns and wounds. The objective of this study was to verify the traditional claims by aqueous and ethanolic extracts of the root part of Thespesia macrophylla for its wound healing property by using animal models. Excision and Incision wound models were adopted and animals were divided into four groups of control and treatments. The animal groups were topically treated with prepared ointment containing 5%w/w of aqueous and ethanol extracts of Thespesia macrophylla and nitrofurazone ointment respectively. The progressive changes in wound area were monitored planimetrically by tracing the wound margin on graph paper every alternate day. It was observed that the wound contracting ability of the 5% (w/w) ethanolic extract ointment treated groups showed significant wound healing from the sixth day onwards. The tissue regeneration was much greater in the wound skin treated with 5%w/w ethanolic extract ointment than 5% w/w aqueous ointment treated without any edema, congestion, or inflammatory changes. In conclusion, the alcoholic extract of Thespesia macrophylla significantly enhanced and accelerated the rate of wound healing enclosure in rats.
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