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IJAPGR SEPT 2013
Soft Gelatin Capsules-Present and Future Prospective as a Pharmaceutical Dosage Forms -A Review
Gurava reddy .R*, Muthukumaran M, Krishnamoorthy B.
The purpose of this review is to special focus on the advances of soft gelatin capsule. The term soft gelatin capsules is commonly abbreviated to 'softgels'.Soft gelatin capsules has an advantages over hard gelatin capsules is to make a liquid formulation containing the drug in a one-piece outer gelatin shell. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. They are suitable for encapsulation of lipid solutions, fish oil, suspensions, or paste-like formulations, making them a useful option when formulating poorly water-soluble drugs. This will inherently lead to better absorption of the active ingredient as compared with delivery in a tablet or as a powder. Development of soft gelatin capsule (soft gel) dosage form is of growing interest for the oral delivery of poorly water soluble compounds (BCS class II or class IV). This review discusses establishment and the on-going development of the manufacturing technology for liquid fill capsules with focus on progress and challenges of soft gelatin capsules formulation in oral administration for improved solubility and as an absorption-enhancing technique. This considerations form a basis for new applications in oral drug delivery.
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