ISSN 2347 - 5102
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IJAPGR SEPT 2013
Drug chirality & its clinical significance evident, future for the development/separation of single enantiomer drug from racemates- The chiral switch.
Sumithira G*, Sujatha M
This review describes the importance and commercial potency of chiral switching of some compounds and their utility. Chiral drugs are made up of molecule with the same chemical structure, but different three-dimensional arrangements. Modern manufacturing has enabled the development of products containing a single molecular arrangement. The development of this single enantiomer from chiral drugs is known as chiral switching. Enantiomer of the same drug can have different pharmacodynamic and pharmacokinetic properties. Over the decade the drug chirality, particularly the use of single enantiomer versus racemic mixtures, has become an area of considerable interest as a result of advances in the chemical technologies associated with the synthesis, separation and analysis of the individual enantiomers present in a racemates. In addition to new chemical entities a number of “old” racemates have been re-evaluated as potential single enantiomer products with the possibility for an improved therapeutic profile. However, not all these re-evaluations have resulted in the expected therapeutic benefits and unpredicted adverse reactions have resulted. Recently drug companies are increasingly using chiral switching as a marketing strategy. But, before prescribers switch to single enantiomer drugs they should look for evidence from well-conducted clinical trials that show the chiral switch is cost-effective and improves the outcomes for patients rather than patents.
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